Cold Agglutinin Disease

Clinical Cases

When the A1c Doesn’t Fit the Patient

An unexpected clue to compensated hemolysis

When the CBC Won’t Report

Cold agglutinin syndrome revealing lymphoma

When Infection Triggers Hemolysis

Influenza-associated flare in cold agglutinin disease

When the CBC Doesn’t Make Sense

Cold agglutinin disease distorting red cell indices

When the Blood Type Suddenly Changes

Cold agglutinins disrupting ABO typing

When “Macrocytic Anemia” Was Something Else

Cold agglutinin disease evolving over time

When the DAT Keeps Changing

Evolving serology and diagnostic uncertainty in autoimmune hemolytic anemia

When the CBC Cannot Be Trusted

Cold agglutinins distorting automated blood counts

Complement or Clone?

Choosing the right strategy in cold agglutinin disease