- About this Module
- Co-Editors Welcome
- Introduction
- The History of CAD
- Definitions & Classification
- Pathophysiology
- Evolutionary Medicine
- Epidemiology
- Clinical Presentation
- Diagnosis
- Treatment
- Longitudinal Care
- Patient and Clinician Resources
- Consult Practice
- Humanities, Meaning & Experience
- Landmark Studies in CAD
- Beyond the Guidelines
- Clinical Cases
- Test Your Understanding
- Clinical Practice Guidance and Expert Reviews in CAD
- Media Library
Dear Learners,
Welcome to the Cold Agglutinin Disease (CAD) module on The Blood Project (TBP) Website. This module brings together essential information about CAD in one central, easy-to-navigate location—designed especially for medical students and physicians in training.
Here, you’ll find a wide range of content formats, including tutorials, case studies, quizzes, podcasts, and short videos—all created with the goal of promoting critical thinking and deepening clinical understanding.
In keeping with TBP’s commitment to the humanities, we also feature patient perspectives that shed light on the lived experience of CAD.
This module is the second in a growing series of disease-specific hubs and serves as a model for how we’ll present content moving forward. We welcome your feedback as we continue to refine the material and enhance the learning experience.
Meet the Co-Editors

Catherine Broome, MD
Co-Editor, CAD Module
Dr. Broome is Professor of Medicine at Georgetown University’s Lombardi Cancer Center, where she specializes in benign hematologic disorders and serves as a mentor in the Cura Personalis fellowship program. Her research focuses on complement-mediated hematologic conditions, including cold agglutinin disease, PNH, and aHUS.

Ishan J. Tatake, MD
Co-Editor, CAD Module
Ishan Tatake MD completed medical school at the University of Connecticut School of Medicine followed by Internal Medicine residency and hematology/oncology fellowship at the Beth Israel Deaconess Medical Center in Boston, MA. His clinical focus is in classical hematology and hematologic malignancies and his research focus is in Systems-Based Hematology and quality improvement.