Treatment Strategy: Treat the Patient, the Challenge, and the Mechanism
Start treatment by asking what bleeding problem, hemostatic challenge, and VWD mechanism are present
Desmopressin: Borrowing From the Endothelium
How DDAVP mobilizes stored endogenous VWF and why it works only in selected patients
The Desmopressin Trial
Why DDAVP response must be measured as magnitude and durability, not assumed by subtype
VWF Replacement Therapy
When endogenous VWF is absent, unsafe, inadequate, or too short-lived, replacement becomes central
Antifibrinolytics and Local Hemostatic Support
Protect the clot where VWD often bleeds: mucosa, wounds, dental sites, and reproductive tissues
VWF Replacement Products and Dosing
How replacing VWF means replacing function, not just correcting a number
Pharmacokinetics of VWF Concentrate Use
Watch Dr. Robert Sidonio explain individualized pharmacokinetic dosing of VWF concentrates
Novel Therapies for VWD
Watch Dr. Peter Lenting review emerging therapies and future treatment strategies for von Willebrand disease
Peri-procedural Management of VWD
Watch Dr. Frank Leebeek review perioperative management strategies for patients with von Willebrand disease
Genomic Editing Approaches to Treating VWD
Watch Dr. Jeroen Eikenboom explore genomic editing strategies for treating von Willebrand disease
The Use of DDAVP in VWD
Watch Dr. Schols discuss the use of DDAVP in treating for von Willebrand Disease