von Willebrand Disease

Pathophysiology

VWF in One Picture: Jobs, Locations, and Failure Modes

See how one molecule connects vessel wall, platelets, factor VIII, flow, storage, and clearance

Structure-Function That Matters Clinically

Learn how VWF architecture predicts phenotype, lab patterns, subtype, and treatment response

Multimers, Shear, and ADAMTS13

Understand why VWF size, blood flow, and proteolytic trimming determine bleeding and thrombosis risk

Multiple Functions of VWF

Watch Dr. Ferdows Atiq explore the expanding biological functions of von Willebrand factor beyond hemostasis

Animal Models of VWD

Watch Dr. Cécile Denis explore how animal models have advanced von Willebrand disease research

Cellular Models for VWF Investigation

Watch Dr. Mackenzie Bowman compare cellular models used to investigate VWF and VWD

VWD and Angiogenesis

Watch Dr. Anna Randi discuss VWF, angiogenesis, and gastrointestinal angiodysplasia in VWD