von Willebrand Disease

Clinical Cases

A Moving Target: Low VWF versus Type 1 von Willebrand Disease

How a level that drifts with age, pregnancy, and the definition itself makes a poor master, and how even desmopressin, the treatment, carries its own risk.

One Missing Protein, Two Failing Systems: Type 3 von Willebrand Disease

When von Willebrand factor is nearly absent, the platelet loses its anchor and factor VIII loses its protector, and even the vessel wall grows restless.

A Bleed With No History: Reasoning a Path to Type 2M von Willebrand Disease

When von Willebrand factor is present in a normal amount and normally assembled, yet still cannot grip the platelet.

When VWF Cannot Protect Factor VIII

Delivery and delayed postpartum hemorrhage in type 2N von Willebrand disease

What Happens When the Hemostatic Plan Is Missed

Postoperative bleeding, rescue therapy, and prevention in type 2B von Willebrand disease

When an Abnormal Test Is Not Enough

Reconsidering the diagnosis of von Willebrand disease during pregnancy

When Bleeding Reveals an Acquired Hemostatic Disorder

Acquired von Willebrand syndrome in Waldenström macroglobulinemia