- What is a Topic Module?
- Navigating the Module
- Co-Editors Welcome
- Overview of TTP
- History of Medicine
- Eponyms
- Definitions
- Classification
- Pathophysiology
- Clinical Presentation
- Diagnosis
- Treatment
- Treatment in Action
- Post-Discharge Care
- Refractory TTP
- Hereditary TTP
- TTP in Pregnancy
- Video Lectures
- Infographics
- Peripheral Smears
- Case Studies
- Journal Club
- Quizzes
- Frequently Asked Questions
- Patient Experiences
- Pocket Guide for Clinicians
- Information for Patients
- Clinical Practice Guidelines
- Beyond the Guidelines
- Visual Arts
- Ethical Considerations
- References
Welcome to the TTP Topic Module
Thrombotic Thrombocytopenic Purpura (TTP) is a rare but potentially life-threatening disorder caused by deficiency of a von Willebrand factor–cleaving protease. This module brings together everything you need to know about TTP in one place.
Our Topic Modules are designed as 360-degree, one-stop hubs for hematology diseases—far more comprehensive than what you’ll find in textbooks or standard online references.

Two features set these modules apart:
1. Breadth of Content
We go beyond the core clinical domains of epidemiology, pathophysiology, diagnosis, and treatment. You’ll also find topics rarely gathered in one place, e.g.:
- History of medicine
- Eponyms
- Evolutionary perspectives
- Comparative physiology
- Patient narratives
- Ethical considerations
2. Variety of Formats
Learning isn’t limited to text. We use a multimedia approach that incorporates diverse formats rarely found together in a single resource, including:
- Infographics
- Podcasts
- AI-generated explainer videos
- Expert video lectures
- Peripheral smears
- Case studies
In short, our distinctiveness lies across two axes: the breadth of content and the diversity of presentation.
TTP is our first Topic Module. It will serve as the model for future disease-specific modules, as well as modules focused on clinical approaches.
We hope you enjoy exploring this resource—and we welcome your feedback to help us keep improving the learning experience.
Co-Editors:
Brian J Carney
X. Long Zheng
Contributors:
William C Aird
Kevin Barnum
Azra Borogovac
Brian J Carney
Spero Cataland
Shruti Chaturvedi
John Chilton
James N George
Ashley Hallice
Marlene Healy
Contributors:
Kristin LaFollette
Helen Osborne
Flora Payvandi
Bentley Rodrigue
Zachary R Schoepflin
Marie Scully
Ishan J Tatake
Lester Zamora
X. Long Zheng
Developed with support from an unrestricted educational grant from Sanofi.