What is the Mpl receptor?

By William Aird

Receptor for murine myeloproliferative leukemia virus, subsequently discovered to be the receptor for thrombopoietin, the primary driver of platelet production.

MPL is the human homolog v-mpl, viral oncogene that is responsible for transforming myeloproliferative leukemia virus (MPLV)-infected hematopoietic progenitors. MPL has two isoforms (MPL-P and MPL-K) which differ at their 3′ ends due to alternative splicing, leading to distinct cytoplasmic domains. MPL-P is the dominant form, and is responsible for signal transduction. Source.

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