Nov

7

2021

What is the Mpl receptor?

By William Aird

A

What is the Mpl receptor?

Receptor for murine myeloproliferative leukemia virus, subsequently discovered to be the receptor for thrombopoietin, the primary driver of platelet production.

MPL is the human homolog v-mpl, viral oncogene that is responsible for transforming myeloproliferative leukemia virus (MPLV)-infected hematopoietic progenitors. MPL has two isoforms (MPL-P and MPL-K) which differ at their 3′ ends due to alternative splicing, leading to distinct cytoplasmic domains. MPL-P is the dominant form, and is responsible for signal transduction. Source.

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