Warfarin is the most common vitamin K antagonist (VKA) in clinical use:
- Racemic mixture of two optically active isomers, the R and S enantiomers.
- Highly water soluble.
- Rapidly absorbed from the GI tract.
- High bioavailability.
- Reaches maximal blood concentrations about 90 min after oral administration.
- Half-life of 36 to 42 h.
- Metabolized in liver by cytochrome enzymes.
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