What is warfarin?

By William Aird

Warfarin is the most common vitamin K antagonist (VKA) in clinical use:

  • Racemic mixture of two optically active isomers, the R and S enantiomers.
  • Highly water soluble.
  • Rapidly absorbed from the GI tract.
  • High bioavailability.
  • Reaches maximal blood concentrations about 90 min after oral administration.
  • Half-life of 36 to 42 h.
  • Metabolized in liver by cytochrome enzymes.

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