- The most common type; accounts for about 60%-85% of cases.
- The mildest form of disease.
- Autosomal dominant inheritance.
- Sequence variants absent in about 35% of patients.
- Plasma vWF level < 30 units/dL, parallel reduction in factor VIII levels.
- Variable degrees of bleeding.
- Bleeding in type 1 vWD is caused by a decrease in concentration of vWF, not a selective reduction in large multimers. All multimers are present in decreased amounts.
- Concordant reduction in VWF activity and antigen.
- About 15% of cases (called type 1C) are associated with increased clearance of VWF.
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