What is the prevalence of macrocytosis?

By William Aird

Macrocytosis occurs in about 3% of the general population.

The variability in year of publication, statistical rigor, the mean cell volume (MCV) cutoff used to define macrocytosis and the different patient populations account for many differences in prevalence. The higher the MCV cutoff, the lower the prevalence of macrocytosis. Prevalence is higher with age. Most studies show higher prevalence of macrocytosis in males compared to females.