Etoposide- and dexamethasone-based treatment protocol for patients with HLH:
- Standard of care in children.
- A more individualized approach regarding dosing (for example IV dexamethasone 10 mg/m2/day with or without modified dose of etoposide) and duration of HLH-94 is usually adopted in adults.
- Cyclosporine A (CSA)
- Intrathecal therapy
Goals are to:
- Delete activated T cells.
- Suppress inflammatory cytokine production.