What is the differential diagnosis of eosinophilia?

By William Aird

Reactive (secondary):

  • Drug reactions
  • Allergy/hypersensitivity reaction
  • Infections (especially tissue-invasive parasites, such as strongyloides)
  • Cancer
  • Sarcoidosis
  • Connective tissue diseases
  • Adrenal insufficiency
  • Pulmonary diseases such as eosinophilia pneumonia

Clonal (primary):

  • Chronic eosinophilic leukemia
  • Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRAPDGFRB, or FGFR1, or with PCM1-JAK2
  • Other acute and chronic primary bone marrow processes such as myeloproliferative neoplasms