What is non-transferrin-bound iron (NBTI)?

By William Aird

Free, unbound iron in the plasma. Consists of multiple chemical structures of iron (including labile plasma iron) associated with other plasma components. Typically appear when transferrin saturation > 70%. Rapidly taken up by parenchymal cells of the liver, heart, anterior pituitary cells and pancreas, where they generate reactive oxygen species and cause organ damage.

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