- Iron levels
- Iron increases hepcidin levels.
- Represents a feedback mechanism to maintain stable body iron levels.
- Inflammation
- Leads to increased hepcidin levels.
- Represents a host defense mechanism to limit extracellular iron availability to microbes.
- Erythropoiesis
- Increased erythroid activity leads to decreased hepcidin levels.
- Ensures iron supply for erythropoiesis.
- Erythropoietic drive overrides both iron sensing and inflammation sensing mechanisms to control hepcidin levels.
Jun
14
2022