What are the subtypes of type 2 von Willebrand disease (vWD)?

By William Aird

  • Type 2A – decreased secretion or increased cleavage of high-molecular-weight multimers.
  • Type 2B – increased vWF binding to platelet glycoprotein Ib (GPIb) alpha receptor with rapid clearance of platelet-vWF complex.
  • Type 2M – defective binding to platelet GPIb alpha receptor or collagen; M for multimer.
  • Type 2N – defective vWF binding to factor VIII; N for Normandy, where it was discovered.

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