What are the indications for replacement therapy in patients with disseminated intravascular coagulation (DIC)?
ISTH/SSC Harmonization of the recommendations:
- Fresh frozen plasma (FFP) recommended in patients with active bleeding or requiring an invasive procedure and either prolonged PT/aPTT (> 1.5 × normal) or decreased fibrinogen (< 1.5 g/L).
- Cryoprecipitate recommended for patients with active bleeding plus severe hypofibrinogenemia (< 1.5 g/L) that persists despite FFP replacement.
- Platelet transfusion recommended in patients with active bleeding plus platelet count < 50 × 109/L, or high risk of bleeding plus platelets < 20 × 109/L.