What are the indications for replacement therapy in patients with disseminated intravascular coagulation (DIC)?

ISTH/SSC Harmonization of the recommendations:

• Fresh frozen plasma (FFP) recommended in patients with active bleeding or requiring an invasive procedure and either prolonged PT/aPTT (> 1.5 × normal) or decreased fibrinogen (< 1.5 g/L).
• Cryoprecipitate recommended for patients with active bleeding plus severe hypofibrinogenemia (< 1.5 g/L) that persists despite FFP replacement.
• Platelet transfusion recommended in patients with active bleeding plus platelet count < 50 × 10⁹/L, or high risk of bleeding plus platelets < 20 × 10⁹/L.