National Comprehensive Cancer Network (NCCN) and European LeukemiaNet (ELN) recommend WHO 2016 diagnostic criteria (above) for most accurate diagnosis. Hemoglobin thresholds for men and women were lowered in the 2016 revision to the WHO diagnostic criteria (16.5 g/dL for men or 16 g/dL for women) to include most cases of masked PV that were missed by the 2008 WHO criteria (18.5 g/dL for men and 16.5 g/dL for women).
