Is a low fibrinogen sensitive for diagnosing DIC?

By William Aird

No. There are 4 parameters that are used in clinical scoring systems for DIC: fibrinogen, prothrombin time (PT), platelet count and D-dimers/fibrin degradation products. Fibrinogen is the least sensitive of these markers (overall sensitivity of low fibrinogen level reported to be 28%) because it is an acute phase reactant and therefore often elevated in conditions associated with DIC.