Döhle Bodies

By William Aird

Döhle body in neutrophil (5 o’clock, arrow) from a 49-year-old man with bacteremia (100x, oil).

Döhle body in neutrophil (10 o’clock, arrow) from an 82 year-old man with sepsis (100x, oil).
Döhle body in neutrophil (8 o’clock, arrow) from a 49 year-old man with bacteremia (100x, oil).
White blood cell, inclusionDöhle body
DefinitionDöhle bodies appear as single or multiple blue or gray-blue inclusions in the cytoplasm (typically near the cell membrane) of neutrophils bands, or metamyelocytes. Their size varies (0.1 to 5.0 μm) as does their shape (round, crescent or or elongated).
DdxDöhle-like inclusion bodies in May Hegglin anomaly, Flechtner syndrome, Sebastian syndrome, and Epstein syndrome
Conditions associated with the phenotypeSeen in conditions associated with increase cytokine release such as infection, burns, trauma, and G-CSF
Mechanism of formationToxic changes, including Döhle bodies, toxic granulation and vacuoles result from the action of cytokines released in response to infection, burns, trauma, and G-CSF. Dohle bodies consist of ribosomes and rough endoplasmic reticulum
HistoryDöhle first described Dohle bodies in the German literature 1911 1
Source/authorWilliam Aird
Reviewed and edited byParul Bhargava
ReferencesCollege of American Pathologists (CAP)2