Quiz on TTP Clinical Presentation • The Blood Project

What 5 clinical findings make up the classic TTP pentad?

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Thrombocytopenia
Microangiopathic hemolytic anemia
Neurologic symptoms
Kidney impairment
Fever

The classic pentad is present in what percentage of patients?

a

1%

b

5-10%

c

10-20%

d

20-30%

e

>40%

What is the most common organ dysfunction seen in TTP?

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Neurological

True or false: Renal failure is common in TTP.

a

True

b

False

True or false: Because the thrombocytopenia in TTP reflects the formation of occlusive platelet clots, bleeding is rarely seen in patients with TTP.

a

True

b

False

True or false: The PT and aPTT are typically elevated in patients with TTP.

a

True

b

False

What is the median platelet count in a patient with TTP at presentation?

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10–30 × 10⁹/L

Which of the following serum levels are often elevated in patients with TTP:

a

Haptoglobin

It is reduced in patients with TTP

b

LDH

c

Troponin

>50% of cases

d

Direct bilirubin

It is indirect bilirubin that is increased in hemolysis