Have you ever been consulted to see a patient with liver disease who may be hemolyzing? These are challenging cases because the usual hemolytic markers are also abnormal in liver disease.
- 1979 – First protein-based study of red blood cells
- 2006 – In-depth analysis of the membrane and cytosolic proteome of erythrocytes revealed:
- 314 membrane proteins
- 252 cytosolic proteins
- 2013 – More advanced proteomic techniques yielded 2,289 proteins in red blood cells.
- 2017 – The most recent proteomic study revealed 2650 proteins, of which 1890 occurred at more than 100 copies per cell.
Surely there are undiscovered specific hemolytic markers somewhere in the mix!
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