Knowledge Check

The above labs were taken on the same day from a 72 yo M in the hospital.

The above labs were taken on the same day from a 72 yo M in the hospital.

The above labs were taken on the same day from a 72 yo M in the hospital.

Which of the above SPEP tracings most resembles that described in the results (A is normal).

a
A
Normal tracing
b
B
Low albumin band
c
C
Hypogammaglobulinemia

The above labs were taken on the same day from a 72 yo M in the hospital.

True or false: The CRP is elevated, so the ESR must be as well.

a
True
b
False
There are occasional instances of discordance between CRP and ESR. For example, if the patient had DIC and low fibrinogen, the ESR might not be elevated.

The above labs were taken on the same day from a 72 yo M in the hospital.

The above labs were taken on the same day from a 72 yo M in the hospital.

True or false: The changes in the complete blood count are considered acute phase proteins/reactants.

a
True
b
False
They are considered to be part of the acute phase RESPONSE.

Sort the protein according to whether it is a positive or negative acute phase reactant or neither

Transferrin
Fibrinogen
Ferritin
Creatine kinase
Albumin
Thyroid stimulating hormone
CRP
Erythropoietin
Hepcidin
Haptoglobin
Serum amyloid P
Creatinine
Positive APR
Negative APR
Not an APR

True or false: acute phase proteins are not just markers for diagnosis and prognosis; they play a role in the adaptive response to injury and infection.

a
True
b
False

Which is the most important cytokine mediating changes in the expression of acute phase proteins:

a
IL-1
b
IL-11
c
TNF-alpha
d
IL-6
e
G-CSF

IL-6-mediated changes in the expression of acute phase proteins occurs primarily at what level:

a
Transcriptional
b
Post-transcriptional

What is the most common cellular source of acute phase proteins:

a
Peritubular cells of kidney
b
Liver hepatocytes
c
Endothelial cells
d
Red blood cells
e
Cerebellar Purkinje cells
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