Knowledge Check

Drag and drop the cards with clinical parameters on the top to the appropriate bucket (TTP pentad or not) on the bottom.

MAHA

Neurological findings

ADAMTS13 < 10%

Skin rash

Fever

Renal dysfunction

Low vWF levels

Thrombocytopenia

Schistocytes on blood smear

Part of pentad

Not part of pentad

Continue

MAHA, macroangiopathic hemolytic anemia

The pentad is present in only 5% of patients with thrombotic thrombocytopenic purpura.

Which two components of the pentad are now considered acceptable to make a diagnosis of TTP?

Click for Answer

1. MAHA
2. Thrombocytopenia

True of false: the direct antiglobulin test (DAT, also called Coombs test) is typically positive in patients with thrombotic thrombocytopenic purpura (TTP).

True of false: congenital thrombotic thrombocytopenic purpura (TTP) is more common than the acquired form.

True of false: red cell transfusion is relatively contraindicated in patients with thrombotic thrombocytopenic purpura (TTP).

Which of the following should be started in all patients with a first episode of suspected thrombotic thrombocytopenic purpura (TTP):