Knowledge Check
![](https://www.thebloodproject.com/wp-content/uploads/2022/05/shutterstock_2087465170-1024x788.png)
Drag and drop the cards with clinical parameters on the top to the appropriate bucket (TTP pentad or not) on the bottom.
![](https://www.thebloodproject.com/wp-content/themes/3MW-gutenberg/assets/images/one.png)
![](https://www.thebloodproject.com/wp-content/themes/3MW-gutenberg/assets/images/one.png)
MAHA, macroangiopathic hemolytic anemia
The pentad is present in only 5% of patients with thrombotic thrombocytopenic purpura.
![TheBloodProject-logo-initials](https://www.thebloodproject.com/wp-content/uploads/2021/10/TheBloodProject-logo-initials.jpg)
![TheBloodProject-logo-initials](https://www.thebloodproject.com/wp-content/uploads/2021/10/TheBloodProject-logo-initials.jpg)
![TheBloodProject-logo-initials](https://www.thebloodproject.com/wp-content/uploads/2021/10/TheBloodProject-logo-initials.jpg)
![TheBloodProject-logo-initials](https://www.thebloodproject.com/wp-content/uploads/2021/10/TheBloodProject-logo-initials.jpg)
![TheBloodProject-logo-initials](https://www.thebloodproject.com/wp-content/uploads/2021/10/TheBloodProject-logo-initials.jpg)
Which two components of the pentad are now considered acceptable to make a diagnosis of TTP?
Click for AnswerTrue of false: the direct antiglobulin test (DAT, also called Coombs test) is typically positive in patients with thrombotic thrombocytopenic purpura (TTP).
True of false: congenital thrombotic thrombocytopenic purpura (TTP) is more common than the acquired form.
True of false: red cell transfusion is relatively contraindicated in patients with thrombotic thrombocytopenic purpura (TTP).
Which of the following should be started in all patients with a first episode of suspected thrombotic thrombocytopenic purpura (TTP):