Cabot Rings

By William Aird

InclusionCabot ring
DefinitionToxic granulation is the presence of large purple or dark blue cytoplasmic granules (primary granules) in neutrophils, bands, and metamyelocytes. The granules have increased staining density compared to normal neutrophils
DdxEDTA storage may produce degenerative vacuolization
Conditions associated with the phenotypeSeen in conditions associated with increase cytokine release such as infection, burns, trauma, and G-CSF
MechanismToxic changes result from the action of cytokines released in response to infection, burns, trauma, and G-CSF (granulocyte colony stimulating factor) and indicate a shortened maturation time and activation of postmitotic neutrophil precursors owing to decreased transit time in bone marrow
Other findings to look forOften seen with toxic vacuolation, Dohle bodies. Together these three findings are referred to as toxic changes
Source/authorWilliam Aird
Reviewed and edited byParul Bhargava