Answer to Hb Electrophoresis

While we do not have sequencing information for this patient, the data are most consistent with presence of Hb C and beta+-thal in cis on the same beta gene allele (HBB).


I cannot find any similar examples in the literature, though there are a couple reports of beta+-thal in cis with the sickle gene (e.g., PMID: 2790205).