History Taking In TTP

Ask about:

• Bleeding, especially:
  • Cutnaeous
  • Gastrointestinal
  • Menstrual
• Fever 
• Symptoms of end organ damage:
  • Neurological manifestations:
    • Headache
    • Cognitive changes
    • Focal deficit
    • Syncope
    • Seizure
    • Visual changes
  • Gastrointestinal manifestations:
    • Nausea and vomiting
    • Abdominal pain
    • Diarrhea
  • Cardiac manifestations:
    • Chest pain
    • Symptoms of heart failure
• History/symptoms of underlying conditions associated with secondary TTP:
  • SLE
  • Rheumatoid arthritis
  • HIV infection
  • Pregnancy
• History of triggers (especially for hereditary TTP):
  • Fever
  • Infection
  • Vaccination
  • Pregnanc
  • Dehydration
• Use of drugs associated TTP:
  • Ticlopidine
  • Quinine
  • Simvastatin
  • Trimethoprim
  • Pegylated interferon
  • Calcineurin inhibitors

Want to explore this further?

Check out the related sections in our TTP module:

• TTP – Clinical Presentation
• TTP – Physical Exam
• TTP Clinical Presentation – Quiz