Q: Which laboratory markers can help distinguish hemolysis from mimics like cirrhosis or vitamin B12 deficiency?

Hemolysis : reticulocytosis, low haptoglobin, hemoglobinuria (if intravascular). Cirrhosis : may raise indirect bilirubin but typically without low haptoglobin or reticulocytosis. B12 deficiency : can elevate LDH and indirect bilirubin due to intramedullary RBC death, but smear shows macrocytosis and hypersegmented neutrophils.

Q: Which laboratory markers can help distinguish hemolysis from mimics like cirrhosis or vitamin B12 deficiency?

Hemolysis : reticulocytosis, low haptoglobin, hemoglobinuria (if intravascular). Cirrhosis : may raise indirect bilirubin but typically without low haptoglobin or reticulocytosis. B12 deficiency : can elevate LDH and indirect bilirubin due to intramedullary RBC death, but smear shows macrocytosis and hypersegmented neutrophils.

Question 1

Which laboratory markers can help distinguish hemolysis from mimics like cirrhosis or vitamin B12 deficiency?

William Aird · Accepted Answer

Hemolysis: reticulocytosis, low haptoglobin, hemoglobinuria (if intravascular).
Cirrhosis: may raise indirect bilirubin but typically without low haptoglobin or reticulocytosis.
B12 deficiency: can elevate LDH and indirect bilirubin due to intramedullary RBC death, but smear shows macrocytosis and hypersegmented neutrophils.

Question 2

Which laboratory markers can help distinguish hemolysis from mimics like cirrhosis or vitamin B12 deficiency?

William Aird · Accepted Answer

Hemolysis: reticulocytosis, low haptoglobin, hemoglobinuria (if intravascular).
Cirrhosis: may raise indirect bilirubin but typically without low haptoglobin or reticulocytosis.
B12 deficiency: can elevate LDH and indirect bilirubin due to intramedullary RBC death, but smear shows macrocytosis and hypersegmented neutrophils.

Which laboratory markers can help distinguish hemolysis from mimics like cirrhosis or vitamin B12 deficiency?

Which laboratory markers can help distinguish hemolysis from mimics like cirrhosis or vitamin B12 deficiency?

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