Jul

4

2022

What is the treatment of choice for atypical hemolytic uremic syndrome (aHUS)?

By William Aird

Eculizumab, a monoclonal anti-C5 antibody that blocks the entry of C5 into C5 convertase.

141 Legendre CM, Licht C, Muus P, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med 2013; 368: 2169–81. 142 Licht C, Greenbaum LA, Muus P, et al. Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies. Kidney Int 2015; 87: 1061–73. 143 Fakhouri F, Hourmant M, Campistol JM, et al. Terminal complement inhibitor eculizumab in adult patients with atypical hemolytic uremic syndrome: a single-arm, open-label trial. Am J Kidney Dis 2016; 68: 84–93. 144 Fakhouri F, Hourmant M, Campistol JM, et al. Eculizumab inhibits thrombotic microangiopathy, and improves renal function in adult atypical hemolytic uremic syndrome patients: 1-year update. J Am Soc Nephrol 2014; 25: 751A

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