Jun

19

2022

What is  platelet refractoriness?

By William Aird

Repeated failure to achieve adequate response to platelet transfusions. variably defined as:

  • Corrected count increment (CCI) of < 5 × 109/L at 1 hour post transfusion after 2 sequential transfusions of ABO-compatible platelets, with ≥ 1 transfusion using platelets stored ≤ 48 hour.
  • CCI of < 5 × 109/L/m2 at 1 hour; < 10 × 109/L at 16-24 hours.
  • CI of < 10 × 109/L at 1 hour; < 2.5 × 109/L/m2 at 16-24 hours.
  • Platelet recovery of < 20% at 1 hour; < 10% at 16-24 hours.