Jul

5

2022

What is Donath–Landsteiner syndrome?

By William Aird

Paroxysmal cold hemoglobinuria (PCH), a form of cold-reactive autoimmune hemolytic anemia activated primarily by polyclonal IgG antibodies (Donath–Landsteiner antibody). PCH activates complement at cold temperatures. Complement activation is via P-antigen binding on RBCs with subsequent intravascular hemolysis being initiated upon rewarming to normal body temperatures.

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