What is a Döhle body?

By William Aird

Döhle bodies appear as single or multiple blue or gray-blue inclusions of variable size (0.1 to 5.0 μm) and shape (round or elongated or crescent shaped) in the cytoplasm of neutrophils, bands, or metamyelocytes. They are often found in the periphery of the cytoplasm, near the cell membrane. Seen in conditions associated with increase cytokine release such as infection, burns, trauma, and administration of G-CSF.

Peripheral smear showing Dohle body (arrow) in a neutrophil