What conditions mimic hemolysis (i.e. they are associated with positive hemolytic markers)?

By William Aird

  • Conditions involving macrophage-mediated ingestion or red cells:
    • Hemophagocytic lymphohistiocytosis (HLH)
    • Pernicious anemia
    • Resorbing hematoma
  • Conditions not associated with red cell destruction:
    • Cirrhosis may also mimic hemolysis because the liver is responsible for synthesizing haptoglobin and hepatocytes release LDH, and AST may be elevated disproportionately to ALT, especially in alcoholic liver disease.