What are the different types of prothrombin complex concentrates (PCCs)?

By William Aird

  • Non-activated PCCs (PCCs):
    • Nonactivated 3-factor PCCs which contain factors II, IX, and X, with negligible factor VII, protein C, and S.
    • Nonactivated 4-factor PCCs which contain factors II, VII, IX, X, and proteins C and S.
  • Activated PCCs (aPCCs):
    • Also called factor VIII inhibitor bypassing agent.
    • Contains small amounts of factor IXa, Xa, and thrombin and large quantities of factor VIIa.