What are some of the physiological adaptations in chronic normovolemic anemia?

By William Aird

  • Increase in cardiac output, primarily from increased stroke volume
  • Increase in 2,3-diphosphoglycerate (2,3-DPG), leading to shift of oxygen dissociation curve to the right (lower affinity for oxygen, increased oxygen unloading in tissues)
  • Increase in oxygen extraction by tissues
  • Redistribution of blood flow to vital tissues such as the brain and heart