Jun

14

2022

What are some of the physiological adaptations in chronic normovolemic anemia?

By William Aird

A

What are some of the physiological adaptations in chronic normovolemic anemia?

  • Increase in cardiac output, primarily from increased stroke volume
  • Increase in 2,3-diphosphoglycerate (2,3-DPG), leading to shift of oxygen dissociation curve to the right (lower affinity for oxygen, increased oxygen unloading in tissues)
  • Increase in oxygen extraction by tissues
  • Redistribution of blood flow to vital tissues such as the brain and heart

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