What are some causes of secondary erythrocytosis?

By William Aird

Conditions associated with:

  • Appropriate release of erythropoietin from oxygen sensing cells in the kidney, including:
    • Cardiopulmonary disease
    • High altitude
    • Hereditary hemoglobin mutations associated with high oxygen affinity
  • Inappropriate release of erythropoietin from:
    • Oxygen sensing cells in the kidney, including renal disorders and drugs
    • Tumor cells
P. vera, polycythemia vera; ODC, oxygen dissociation curve; R-L shunt, right to left shunt; EPO, erythropoietin.

See additional list of causes from PMC7829024. Learn more here.