Less avascular necrosis, pulmonary hypertension, leg ulcers, and stroke; more retinopathy. 0.4% painful crises per patient year in those with HbSC, less than half the rate in sickle cell anemia. Learn more here.
| Complication | HbSC | HbSS |
|---|---|---|
| Avascular necrosis | + | +++ |
| Pulmonary hypertension | + | +++ |
| Leg ulcers | + | +++ |
| Stroke | + | +++ |
| Retinopathy | +++ | + |
| Painful crises | + | +++ |