- Patients with history of severe allergic reactions to plasma-containing products.
- Patients who have absolute immunoglobulin A (IgA) deficiency and for whom no IgA-deficient RBCs are available.
- Patients at risk of hyperkalemia.
- Neonates with neonatal alloimmune thrombocytopenia requiring maternal RBC transfusion that contains antihuman platelet antigen-1a (however, use of washed RBCs is not required.)
According to AABB:
- Description:
- Washed components are typically prepared using 0.9% Sodium Chloride, Injection USP with or without small amounts of dextrose.
- Washing removes unwanted plasma proteins, including antibodies and glycerol from previously frozen units.
- The shelf life of washed components is no more than 24 hours at 1 to 6 C or 4 hours at 20 to 24 C.
- Washing is not a substitute for leukocyte reduction, and only cellular components should be washed.
- Indications:
- To reduce exposure to antibodies targeting known recipient antigens.
- To remove constituents that predispose patients to significant or repeated transfusion reactions (eg, removal of IgA-containing plasma in providing transfusion support for an IgA-deficient recipient or in rare recipients experiencing anaphylactoid/anaphylactic reactions to other plasma components).