What are common serum markers of hemolysis?

By William Aird

Lactate dehydrogenase (LDH), indirect (unconjugated) bilirubin, haptoglobin, and AST. Learn more here.

Hemolysis is associated with elevated serum levels of leakage products, LDH and AST; reduced levels of haptoglobin (Hp) owing to binding to free Hb and internalization in macrophages (without recycling); and elevation of unconjugated (indirect) bilirubin from breakdown of heme inside macrophages.