Oct

26

2021

What are causes of platelet refractoriness?

By William Aird

  • Immune-mediated:
    • Alloimmunization to human leukocyte, platelet-specific, or ABO antigens
    • Autoimmune (immune thrombocytopenia)
  • Non-immune-mediated:
    • Hemorrhage
    • Fever
    • Sepsis
    • Disseminated intravascular coagulation (DIC)
    • Splenic sequestration
    • Use of older stored platelets
    • Thrombotic microangiopathy

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