- Immune-mediated:
- Alloimmunization to human leukocyte, platelet-specific, or ABO antigens
- Autoimmune (immune thrombocytopenia)
- Non-immune-mediated:
- Hemorrhage
- Fever
- Sepsis
- Disseminated intravascular coagulation (DIC)
- Splenic sequestration
- Use of older stored platelets
- Thrombotic microangiopathy
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