Jul

4

2022

What are causes of heparin resistance?

By William Aird

  • Non-specific binding of negatively charged heparin molecules to:
    • Platelet factor 4
    • Histidine-rich glycoprotein
    • Lipoproteins
    • von Willebrand factor
    • Factor VIII
    • Fibrinogen
    • Monocytes
    • Endothelial cells
    • Growth factors
    • Nonendothelial surfaces
      • Intravenous tubing
      • Extracorporeal circuit components
  • Deficiency of antithrombin
    • Congenital
    • Acquired
      • Liver disease
      • Sepsis
      • Acute disseminated intravascular coagulation
      • Asparaginase use in patients with acute leukemia
      • Use of extracorporeal circuits in cardiopulmonary bypass or ECMO

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