Should patients with thrombotic thrombocytopenic purpura (TTP) and very low platelet counts receive platelet transfusions?

By William Aird

No, platelet transfusions may exacerbate the thrombotic tendency in HIT. Platelet transfusion should be reserved for patients with active bleeding or at high risk of bleeding.

2018 American Society of Hematology (ASH) guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia

Consider the following comment from Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura: