Should adults and children with sickle cell disease (SCD) presenting with acute pain be treated with NSAIDs?

By William Aird

Yes, provided there is no increased risk for toxicity.

American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain:

It is good practice to provide
patient-centered education and surveillance related to NSAID
toxicity, especially in patients with end-organ comorbidities, because
long-term safety data for SCD are lacking, but vascular, bleeding,
and renal risks may be elevated.