Jun

14

2022

My patient is taking direct oral factor Xa inhibitor and has a major bleed. What should I do?

By William Aird

A

My patient is taking direct oral factor Xa inhibitor and has a major bleed. What should I do?

  • Consider andexanet alfa.
  • If andexanet alfa is not available, consider 4-factor PCC 50 units/kg IV.
  • If 4-factor PCC is not available, consider activated PCC 50 units/kg IV.
  • Consider activated charcoal for known ingestion within last 2-4 hours.

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