In heparin-induced thrombocytopenia (HIT), how long are patients at risk for developing thrombosis?

By William Aird

Even with platelet count recovery, patients remain at risk for thrombosis for 4 to 6 weeks after diagnosis (~17–53% over a thirty day period) because of circulating anti-PF4/heparin antibodies. While there is consensus among experts that patients with isolated HIT should be treated in the short-term with alternative anticoagulants, there is no firm consensus on the intensity or duration of anticoagulation for this patient population.