It Depends on the Formulation
- Each IV iron product has its own maximum infusion rate and allowable single dose, determined by the stability of the iron–carbohydrate complex.
- Infusion speed is limited not by “toxicity” per se, but by the risk of transient complement activation (Fishbane-type or CARPA reactions) that correlate with how fast free nanoparticles enter the circulation.
Key Takeaways
- Infusion rate is formulation-specific — always follow the product’s label.
- 15–60 minutes is the general range for modern IV irons.
- Observation after infusion is standard for safety.
- Slower rates can reduce benign pseudoallergic (CARPA/Fishbane) reactions.