Jun

14

2022

How do I reverse fondaparinux in a patient with a major bleed?

By William Aird

A

How do I reverse fondaparinux in a patient with a major bleed?

  • No FDA-approved reversal agents for fondaparinux; no specific antidote available.
  • Fondaparinux does not bind to protamine sulfate; therefore protamine sulfate is not recommended.
  • Consider activated PCC (aPCC) 20 units/kg.
  • If aPCC is contraindicated or not available, consider rFVIIa 90 mcg/kg.

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