In patients with synthetic liver dysfunction, the vitamin K cycle is impaired, so even large doses of vitamin K are not effective. Partial response may be seen in those patients who are vitamin K deficient, for example those receiving broad-spectrum antibiotics. Example of a negative study here.
Italian Association for the Study of Liver Diseases (AISF) and the Italian Society of Internal Medicine (SIMI) (AISF/SIMI) recommends against the routine administration of vitamin K to increase the plasma levels of coagulation factors in patients with cirrhosis:
