Oct

11

2021

Can haptoglobin ever be normal in setting of severe hemolysis?

By William Aird

A

Can haptoglobin ever be normal in setting of severe hemolysis?

Rarely, haptoglobin (Hp) levels are normal or increased in hemolysis owing to inhibition of the macrophage uptake of the haptoglobin-hemoglobin complex (Hp-Hb) by the CD163 receptor.

Hb, hemoglobin; Hp, haptoglobin; liver, upper left; lysed red cell, upper right; macrophage, bottom.

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