Published Clinical Trials in Patients with TTP
- Plasma exchange:
- Bell WR et al, Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. N Engl J Med 1991 Aug 8;325(6):398. PMID: 2062331
- Rock et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. (N Engl J Med 1991 Aug 8;325(6):393). PMID: 2062330
- Rituximab:
- Scully M. A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura. Blood 2011 Aug 18;118(7):1746. PMID: 21636861
- Caplacizumab:
- Scully M et al. Long-term follow-up of patients treated with caplacizumab and safety and efficacy of repeat caplacizumab use: Post-HERCULES study. J Thromb Haemost. 2022 Dec;20(12):2810-2822. PMID: 36138517
- Scully M. Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura. N Engl J Med 2019 Jan 24;380(4):335. PMID: 30625070
- Peyvandi F. Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura. N Engl J Med 2016 Feb 11;374(6):511. PMID: 26863353
- Recombinant ADAMTS13:
- Scully M. Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura. N Engl J Med. 2024 May 2;390(17):1584-1596. PMID: 38692292