Model of erythroid EPO/EpoR signaling. The homodimeric EpoR molecule with Janus kinase 2 (JAK2) bound to its cytoplasmic domain is primed for EPO stimulation. EPO binding to the extracellular domain of EpoR results in conformational changes that bring JAK2 bound sites in close proximity to each other. This results in transphosphorylation of JAK2 and activation, which in turn increases other downstream signaling through signal transducer and activator of transcription 5 (STAT5), mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT pathways. From PMCID: PMC4100153
